Ibutamoren, MK677 Review: Effects, risks, and legal alternative

Ibutamoren (also known as Nutrobal, Ibutamoren Mesylate, or MK677) is an orally active muscle-building prohormone used to enhance growth hormone (GH) levels.

Although being marketed as belonging to the SARMs family, Ibutamoren is actually a nonpeptide GH secretagogue.

Despite the fact that it is illegal to sell this steroid for human consumption, it is available online.

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What is Ibutamoren, MK677 used for?

Ibutamoren is most commonly used by bodybuilders looking to gain lean body mass and produce bigger muscles in a short period of time.

The compound delivers by boosting protein synthesis and nitrogen retention in the muscle. The user becomes fuller and more pumped and is bound to recover faster from workouts.

Elderly patients with hip fractures have also been subject to Ibutamoren testing to prevent muscle wasting due to trauma or disease.

The compound helped reduce the number of falls suffered by these patients. Using the steroid has also proven to lower protein loss and muscle wasting in people with unhealthy diets or lifestyles.

In addition, MK677 has helped elderly adults produce stronger bones through increased mineral density and accelerated bone turnover.

This effect was substantiated through a study with post-menopausal women, in which the compound proved effective in preventing osteoporosis.

Some people have also used the compound for its nootropic effects, that is, as a cognitive enhancer.

Ibutamoren may do so indirectly, through the stimulation of the ghrelin receptor, which amplifies REM sleep duration and insulin-like growth factor (IGF-1).

This could be effective in the heightening of memory and learning. Empirical evidence, however, has not yet supported this claim.

Finally, Ibutamoren, MK677 has been used for wound healing and tissue regeneration, another effect of growth hormone increase. Science, though, has yet to determine if the compound can deliver to that purpose.

What is known about this particular benefit is still mainly due to anecdotal evidence.

What are the effects of an Ibutamoren, MK677 Cycle?

As it has been said, Ibutamoren, MK677 allows athletes to rapidly form muscle.

In a matter of one cycle (typically 4-5 weeks), users can gain between 10 and 15 pounds of lean body mass.

Furthermore, the compound will redirect a calorie surplus to lean muscle gains. That would be impossible to achieve in a natural way.

How does it affect your body?

Ibutamoren, MK677 claims to be able to “transform” your body, and it does so in many ways. After ingestion, the compound orders the pituitary gland to secrete more GH.

When released into the bloodstream, GH, in turn, stimulates IGF-1 secretion in the liver.

Though not proven yet in humans, it is believed that additional quantities of IGF-1 may cause cellular hyperplasia, that is, myofiber partition in two, in order to create new muscle fibers.

The consequence is the production of 6-8 brand new pounds of muscle, which can become plenty more when combined with an appropriate cycle of diet and lifts.


Although further scientific research is still needed in order to fully understand the potential of Ibutamoren, MK677, its most important characteristic is, without doubt, the increase in the production of growth hormones.

This comes associated with some benefits. Namely, the following:

  • It boosts protein synthesis and nitrogen retention in the muscles. The results are a bulkier musculature and a speedier recovery after training. This virtuous cycle reinforces itself: followingworkouts and the generation of body mass, the period after which the athlete can get back at it reduces significantly.
  • Something that always bothers bodybuilders is the end of a substance’s cycle because the effects achieved during continued consumption seemed to be lost. Ibutamoren, on the other hand, allows the athletes to remain pumped even during a diet:in the course of minimum calorie ingesting periods, MK677 will cause the body to burn fat instead of glycogen and muscles.
  • It is clear that, at a certain age, the human body stops naturally producing growth hormone. Hearsay evidence about Ibutamoren, MK677 claims that, sinceit boosts the secretion of GH to unseen levels, it provides anti-aging benefits, such as smoother and healthier skin and hair, as well as tougher bones. Users state that they feel better with their bodies overall.
  • The stimulation of the ghrelin receptor amplifies REM sleep duration, which results in better lucid and non-lucid dreams and anoverall sensation of being well-rested. Just what any athlete needs: a good reinvigorating sleep to keep the routine going and not become overwhelmed by it.

Side effects  

Ibutamoren, MK677proponents argue that the substance causes mild to no side effects at all,but the truth is that there have not been exhaustive clinical studies to back that assertion.

Furthermore, one study was terminated due to severe adverse events. Side effects most commonly mentioned include the following:

  • Individuals complain about muscular pain and numb hands.This soreness might makeit difficult for athletes to keep up with their routine in a regular fashion.
  • People have experienced weight gain apart from the increase in lean body mass, especially when the ingestion of the product is not accompanied by a thorough diet. Ibutamoren, MK 677 heightens the appetite, so it is normal for users to increase the intake of calories beyond what they can burn.
  • Consumption of Ibutamoren, MK677 leads to fluid retention,which in turn may result in mild edema (swelling) of the lower extremities.
  • In the long term, the use of this product may lead to insulin resistance, a pathological condition directly related to higher blood sugar levels and possibly type 2 diabetes.
  • Ibutamoren, MK677 could also increase blood pressure and cause heart failure, although the study that yielded these results included elderly patients who already suffered from these ailments.
  • Like any product that boosts growth hormone, this compound is strictly forbidden to cancer patients, since it promotes the enlargement of tumors.
  • Side effects are the same in women. Unlike products that contain male sex hormones, MK677 has no androgenic effects, which means it will not virilize female athletes.

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